CONTACT US
Home > APIs> > Guanabenz Acetate
23256-50-0-Guanabenz Acetate Guanabenz Acetate

Guanabenz Acetate

For research use only. Not for therapeutic Use.

  • CAT Number: A000714
  • CAS Number: 23256-50-0
  • Molecular Formula: C10H12Cl2N4O2
  • Molecular Weight: 291.13
  • Purity: ≥95%
Inquiry Now
Related Small Molecules: Phenformin hydrochloride     Sodium butyrate     Alcaftadine    

Guanabenz acetate is an α2A-AR adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand. Guanabenz acetate is an activator of alpha2B-AR (α2b-adrenergic receptor) and alpha2C-AR (α2c-adrenergic receptor). It is also used as an antihypertensive drug to treat high blood pressure.


Catalog Number A000714
CAS Number 23256-50-0
Synonyms

Guanabenz (Acetate); Wy-8678; 23256-50-0; Wytensin; WY-8678 acetate

Molecular Formula C10H12Cl2N4O2
Purity ≥95%
Target Neuronal Signaling
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
InChIKey MCSPBPXATWBACD-GAYQJXMFSA-N
SMILES CC(=O)O.C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
Reference

1: Igaki N, Yamada H, Oimomi M, Kasuga M. The effective inhibition of the
Maillard reaction by guanabenz acetate, and its relevance to the prevention of
diabetic complications. Clin Chim Acta. 1991 May 31;199(1):113-5. PubMed PMID:
1934497.
<br>

2: Kotake H, Kinugawa T, Hirai S, Matsumoto T, Fukuki M, Hasegawa J, Mashiba H.
Effects of guanabenz acetate on the pacemaker activity of rabbit sinoatrial node
cells. Arch Int Pharmacodyn Ther. 1989 Jul-Aug;300:209-17. PubMed PMID: 2619423.

<br>
3: Spritzer N, Spritzer TS, Rodrigues R. [Guanabenz acetate and serum lipids.
Sequential evaluation during one year]. Arq Bras Cardiol. 1988 Aug;51(2):193-7.
Portuguese. PubMed PMID: 3075114.
<br>

4: LaRusso P, Jessup SA, Rogers FJ, Rogers JC. Sinoatrial and atrioventricular
dysfunction associated with the use of guanabenz acetate. Can J Cardiol. 1988
Apr;4(3):146-8. PubMed PMID: 3378199.

<br>
5: Harvengt C. Drugs recently released in Belgium. Guanabenz acetate,
isotretinoin and etretinate. Acta Clin Belg. 1986;41(1):60-3. PubMed PMID:
3458348.

<br>
6: Tennant FS Jr, Rawson RA. Guanabenz acetate: a new, long-acting alpha-two
adrenergic agonist for opioid withdrawal. NIDA Res Monogr. 1984 Mar;49:338-43.
PubMed PMID: 6090917.
<br>

7: Capuzzi DM, Cevallos WH. Inhibition of hepatic cholesterol and triglyceride
synthesis by guanabenz acetate. J Cardiovasc Pharmacol. 1984;6 Suppl 5:S847-52.
PubMed PMID: 6084138.
<br>

8: Grenfell RF. Double-blind study of guanabenz acetate in hypertensive patients.
South Med J. 1983 Feb;76(2):199-201. PubMed PMID: 6337405.

Request a Quote