For research use only. Not for therapeutic Use.
Guanadrel Sulfate is a postganglionic adrenergic blocking agent. The uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter.
| Catalog Number | R057700 |
| CAS Number | 22195-34-2 |
| Synonyms | N-(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine Sulfate; ?(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine Sulfate; Anarel; CL 1388R; Guanadrel Sulfate; Hylorel; U 28288D; |
| Molecular Formula | C₁₀H₁₉N₃O₂ •1/2H₂SO₄ |
| Purity | ≥95% |
| Storage | Store at +4C |
| Reference | </br>1: Darga LL, Hakim MJ, Lucas CP, Franklin BA. Comparison of the effects of</br> guanadrel sulfate and propranolol on blood pressure, functional capacity, serum</br> lipoproteins and glucose in systemic hypertension. Am J Cardiol. 1991 Mar</br> 15;67(7):590-6. PubMed PMID: 2000792.</br>2: Sekkarie MA, Egan BM, Neubig RR, Supiano MA. Sensitization of human alpha 1-</br> and alpha 2-adrenergic venous responses by guanadrel sulfate. Clin Pharmacol</br> Ther. 1990 Nov;48(5):537-43. PubMed PMID: 2171846.</br>3: Palmer JD, Nugent CA. Guanadrel sulfate: a postganglionic sympathetic</br> inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy.</br> 1983 Jul-Aug;3(4):220-9. PubMed PMID: 6351026.</br>4: Nugent CA, Palmer JD, Ursprung JJ. Guanadrel sulfate compared with methyldopa </br> for mild and moderate hypertension. Pharmacotherapy. 1982 Nov-Dec;2(6):378-83.</br> PubMed PMID: 6762533.</br>5: Cangiano JL, Bloomfield DK. Hemodynamic effects of a new antihypertensive</br> agent, guanadrel sulfate. Curr Ther Res Clin Exp. 1969 Dec;11(12):736-44. PubMed </br> PMID: 4984037.</br>6: Bloomfield DK, Cangiano JL. Clinical experience with a new antihypertensive</br> agent, guanadrel sulfate. Curr Ther Res Clin Exp. 1969 Dec;11(12):727-35. PubMed </br> PMID: 4984036.</br></br> |
