For research use only. Not for therapeutic Use.
Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].
Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1].
| Catalog Number | I028449 |
| CAS Number | 40580-59-4 |
| Synonyms | 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine |
| Molecular Formula | C10H19N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13) |
| InChIKey | HPBNRIOWIXYZFK-UHFFFAOYSA-N |
| SMILES | C1CCC2(CC1)OCC(O2)CN=C(N)N |
| Reference | [1]. J D Palmer, et al. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9. doi: 10.1002/j.1875-9114.1983.tb03257.x. |
