Guanosine 5′-triphosphate (sodium salt hydrate)

• CAT Number: R065198
• Molecular Formula: C10H14N5O14P3 • 2Na [3H2O]
• Molecular Weight: 621.2
• Purity: ≥95%
• Synonyms: GTP
• Storage: -20°C
• InChI: InChI=1S/C10H16N5O14P3.2Na.3H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;3*1H2/q;2*+1;;;/p-2/t3-,5-,6-,9-;;;;;/m1...../
• InChIKey: ZLLZROALIYHJNQ-LTPGDGGNSA-L
• SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O[C@@H]1COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O.[Na+].[Na+].O.O.O

Guanosine 5′-<wbr></wbr>triphosphate (GTP) acts as a substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication. It is generated by the citric acid cycle and provides a source of energy for protein synthesis and gluconeogenesis, activating substrates in metabolic reactions. GTP is essential for G protein-<wbr></wbr>related signal transduction in second-<wbr></wbr>messenger mechanisms where it is converted to GDP through the action of GTPases.

Reference

1.Ohta, T.,Sarkar, S., and Thach, R.E. The role of guanosine 5/’-triphosphate in the initiation of peptide synthesis. III. Binding of formylmethionyl-tRNA to ribosomes. Proceedings of the National Academy of Sciences of the United States of America 58(4),