For research use only. Not for therapeutic Use.
Guanosine 5′-triphosphate-5′-adenosine triammonium (Cat No.: I040114) is a hybrid nucleoside compound that combines the structural features of guanosine triphosphate (GTP) and adenosine triphosphate (ATP). This molecule is typically used in biochemical research to study nucleotide binding and signaling pathways that involve both purine bases. Its unique structure allows it to interact with various enzymes, receptors, or cellular systems that rely on GTP and ATP for energy transfer or signal transduction. It may have applications in investigating cellular metabolism, protein synthesis, and signal regulation.
| Synonyms | [[(2R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(2R,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate;azane |
| Molecular Formula | C20H36N13O17P3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H27N10O17P3.3H3N/c21-14-8-15(24-3-23-14)29(4-25-8)18-12(33)10(31)6(44-18)1-42-48(36,37)46-50(40,41)47-49(38,39)43-2-7-11(32)13(34)19(45-7)30-5-26-9-16(30)27-20(22)28-17(9)35;;;/h3-7,10-13,18-19,31-34H,1-2H2,(H,36,37)(H,38,39)(H,40,41)(H2,21,23,24)(H3,22,27,28,35);3*1H3/t6-,7-,10?,11?,12+,13+,18-,19-;;;/m1.../s1 |
| InChIKey | JKQIMADCKODNKE-JYSBNCGYSA-N |
| SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)O)O)O)O)N.N.N.N |
| Reference | [1]. Renata Kasprzyk, et al. Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity. Chemistry. 2020 Sep 1;26(49):11266-11275. [2]. Dennis Reichert, et al. Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chem Sci. 2021 Feb 8;12(12):4383-4388. |
