For research use only. Not for therapeutic Use.
Guanylyl imidodiphosphate (Gpp(NH)p) lithium, a non-hydrolyzable GTP analogue, increases adenylate cyclase activity[1][2].
| Catalog Number | I044105 |
| CAS Number | 64564-03-0 |
| Synonyms | tetralithium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate |
| Molecular Formula | C10H13Li4N6O13P3 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H17N6O13P3.4Li/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1 |
| InChIKey | NUKFMILQQVRELO-ZVQJTLEUSA-J |
| SMILES | [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N |
| Reference | [1]. B J Terry, et al. Assembly and disassembly properties of microtubules formed in the presence of GTP, 5′-guanylyl imidodiphosphate, and 5′-guanylyl methylenediphosphate. J Biol Chem. 1980 Nov 10;255(21):10532-6. [2]. H Abou-Issa, et al. Modulation of follicle-stimulating hormone-sensitive rat testicular adenylate cyclase activity by guanyl nucleotides. Endocrinology. 1979 Jan;104(1):189-93. |
