Guineesine

• CAT Number: I012593
• CAS Number: 55038-30-7
• Molecular Formula: C24H33NO3
• Molecular Weight: 383.53
• Purity: ≥95%
• Synonyms: Pipyahyine; (2E,4E,12E)-13-(1,3-Benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
• IUPAC Name: (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
• InChI: InChI=1S/C24H33NO3/c1-20(2)18-25-24(26)14-12-10-8-6-4-3-5-7-9-11-13-21-15-16-22-23(17-21)28-19-27-22/h8,10-17,20H,3-7,9,18-19H2,1-2H3,(H,25,26)/b10-8+,13-11+,14-12+
• InChIKey: FPMPOFBEYSSYDQ-AUVZEZIHSA-N
• SMILES: CC(C)CNC(=O)C=CC=CCCCCCCC=CC1=CC2=C(C=C1)OCO2

Guineesine(CAT: I012593) is a naturally occurring alkaloid primarily found in Piper nigrum (black pepper) and Piper longum (long pepper). It exhibits notable neuromodulatory and anti-inflammatory properties. Guineesine functions as an endocannabinoid reuptake inhibitor (ERI), prolonging the action of endocannabinoids like anandamide by blocking their cellular reabsorption. This mechanism enhances cannabinoid receptor signaling, contributing to its analgesic, antidepressant, and anti-inflammatory effects. Guineesine is of significant interest in neuropharmacology and pain management research, offering potential for developing novel therapeutics targeting the endocannabinoid system to treat chronic pain, mood disorders, and inflammatory conditions.