For research use only. Not for therapeutic Use.
GV-58 is an N-and P / Q-type calcium channel agonist with EC50 values of 7.21 and 8.81 uM, respectively. It has a 20-fold weaker inhibitory effect on CDK kinases and is an optimized compound of ( R ) -roscovitine.
CAS Number | 1402821-41-3 |
Molecular Formula | C18H26N6OS |
Purity | ≥95% |
Target | Neuronal Signaling |
Solubility | 10 mM in DMSO |
Storage | Store at -20°C |
IC50 | 7.21/8.81 uM (N-type/P-Q-type Ca2+ channel) |
IUPAC Name | (2R)-2-[[6-[(5-methylthiophen-2-yl)methylamino]-9-propylpurin-2-yl]amino]butan-1-ol |
InChI | InChI=1S/C18H26N6OS/c1-4-8-24-11-20-15-16(19-9-14-7-6-12(3)26-14)22-18(23-17(15)24)21-13(5-2)10-25/h6-7,11,13,25H,4-5,8-10H2,1-3H3,(H2,19,21,22,23)/t13-/m1/s1 |
InChIKey | DPTXJOUVBMUSGY-CYBMUJFWSA-N |
SMILES | CCCN1C=NC2=C(N=C(N=C21)NC(CC)CO)NCC3=CC=C(S3)C |
Reference | <p style=/line-height:25px/> |