GV-58

• CAT Number: I001539
• CAS Number: 1402821-41-3
• Molecular Formula: C18H26N6OS
• Molecular Weight: 374.5
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 7.21/8.81 uM (N-type/P-Q-type Ca2+ channel)
• IUPAC Name: (2R)-2-[[6-[(5-methylthiophen-2-yl)methylamino]-9-propylpurin-2-yl]amino]butan-1-ol
• InChI: InChI=1S/C18H26N6OS/c1-4-8-24-11-20-15-16(19-9-14-7-6-12(3)26-14)22-18(23-17(15)24)21-13(5-2)10-25/h6-7,11,13,25H,4-5,8-10H2,1-3H3,(H2,19,21,22,23)/t13-/m1/s1
• InChIKey: DPTXJOUVBMUSGY-CYBMUJFWSA-N
• SMILES: CCCN1C=NC2=C(N=C(N=C21)NC(CC)CO)NCC3=CC=C(S3)C

GV-58 is an N-and P / Q-type calcium channel agonist with EC50 values of 7.21 and 8.81 uM, respectively. It has a 20-fold weaker inhibitory effect on CDK kinases and is an optimized compound of ( R ) -roscovitine.

Reference

[1]. Tarr TB, et al. Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome. J Neurosci. 2013 Jun 19;33(25):10559-67.