For research use only. Not for therapeutic Use.
GW 4064（Cat No.:I002951）is a potent and selective agonist of the farnesoid X receptor (FXR), a nuclear receptor that plays a key role in regulating bile acid, lipid, and glucose metabolism. By activating FXR, GW 4064 helps modulate cholesterol homeostasis, reduce bile acid synthesis, and improve insulin sensitivity, making it a valuable compound in research related to metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. Its ability to influence bile acid signaling and liver function positions GW 4064 as a promising candidate for developing therapies targeting metabolic diseases.
| Catalog Number | I002951 |
| CAS Number | 278779-30-9 |
| Synonyms | 3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid |
| Molecular Formula | C28H22Cl3NO4 |
| Purity | ≥95% |
| Target | FXR |
| Solubility | 10 mM in DMSO |
| Storage | 2-8°C |
| IC50 | 15 nM (EC50) |
| IUPAC Name | 3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid |
| InChI | InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+ |
| InChIKey | BYTNEISLBIENSA-MDZDMXLPSA-N |
| SMILES | CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl |
| Reference | </br>1:FXR agonist activity of conformationally constrained analogs of GW 4064. Akwabi-Ameyaw A, Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, McFadyen RB, Miller AB, Navas F 3rd, Parks DJ, Spearing PK, Todd D, Williams SP, Bruce Wisely G.Bioorg Med Chem Lett. 2009 Aug 15;19(16):4733-9. doi: 10.1016/j.bmcl.2009.06.062. Epub 2009 Jun 21. PMID: 19586769 </br>2:Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Akwabi-Ameyaw A, Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Jones SA, Kaldor I, Liu Y, Madauss KP, Marr HB, McFadyen RB, Miller AB, Navas F III, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB.Bioorg Med Chem Lett. 2008 Aug 1;18(15):4339-43. doi: 10.1016/j.bmcl.2008.06.073. Epub 2008 Jun 28. PMID: 18621523 |
