GW-441756

• CAT Number: I003794
• CAS Number: 504433-23-2
• Molecular Formula: C₁₇H₁₃N₃O
• Molecular Weight: 275.31
• Purity: ≥95%
• Synonyms: (3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one
• Target: Protein Tyrosine Kinase/RTK
• Solubility: DMSO: ＜ 11.2 mg/mL
• Storage: 3 years -20C powder
• IC50: 2 nM [1]
• InChI: 1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-
• InChIKey: NXNQLECPAXXYTR-LCYFTJDESA-N
• SMILES: CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC=N4)NC3=O

GW-441756 (Cat.No:I003794) is a selective antagonist of the 5-HT6 receptor, a subtype of the serotonin receptor. It has been studied for its potential in the treatment of cognitive disorders such as Alzheimer’s disease and schizophrenia. GW-441756 may enhance cognitive function by modulating neurotransmitter signaling pathways involved in learning and memory processes.

Reference

[1]. Wood ER, Kuyper L, Petrov KG, Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.
[2]. Eun Joo Jung, Choong Won Kim, Deok Ryong Kim. Cytosolic accumulation of γH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. Exp Mol Med. 2008 June 30; 40(3): 276-285.