For research use only, not for therapeutic use.
GW-5074（Cat No.:I002692）is a selective inhibitor of RAF kinase, particularly c-Raf, a key component of the MAPK/ERK signaling pathway. It has been widely used in research to study cell proliferation, differentiation, and survival, especially in cancer models where aberrant RAF signaling drives tumor growth. By inhibiting RAF kinase, GW-5074 disrupts the MAPK/ERK pathway, leading to reduced tumor cell proliferation and increased apoptosis. This compound is valuable for exploring therapeutic strategies targeting RAF-driven cancers, and its selectivity makes it a critical tool in cancer biology and signal transduction research.
| Catalog Number | I002692 |
| CAS Number | 220904-83-6 |
| Synonyms | (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one |
| Molecular Formula | C₁₅H₈Br₂INO₂ |
| Purity | ≥95% |
| Target | Raf |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| IC50 | 9 nM |
| IUPAC Name | (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one |
| InChI | InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3- |
| InChIKey | LMXYVLFTZRPNRV-KMKOMSMNSA-N |
| SMILES | C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2 |
| Reference | </br>1:Intrathecal delivery of farnesyl thiosalicylic acid and GW 5074 attenuates hyperalgesia and allodynia in chronic constriction injury-induced neuropathic pain in rats. Jaggi AS, Singh N.Neurol Sci. 2013 Mar;34(3):297-304. doi: 10.1007/s10072-012-0991-3. Epub 2012 Mar 2. PMID: 22382741 </br>2:Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. Jaggi AS, Singh N.Food Chem Toxicol. 2012 May;50(5):1295-301. doi: 10.1016/j.fct.2012.01.038. Epub 2012 Feb 4. PMID: 22326968 |
