For research use only. Not for therapeutic Use.
GW284543 (CAT: I019083), also known as UNC10225170, is a potent and selective inhibitor of MEK5, a crucial component of the MAPK/ERK signaling pathway. By specifically targeting MEK5, GW284543 disrupts the phosphorylation of ERK5 (pERK5), leading to downregulation of downstream signaling events. Notably, this compound exerts an inhibitory effect on endogenous MYC protein levels. GW284543’s unique mode of action makes it a promising candidate for exploring therapeutic interventions that target dysregulated MAPK/ERK signaling, potentially finding applications in the treatment of various diseases, including cancer and other disorders involving aberrant MYC expression.
| Catalog Number | I019083 |
| CAS Number | 790186-68-4 |
| Molecular Formula | C₂₃H₂₀N₂O₃ |
| Purity | ≥95% |
| Target | MEK |
| Reference | [1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. |
