GW3965

• CAT Number: I003478
• CAS Number: 405911-09-3
• Molecular Formula: C33H31ClF3NO3
• Molecular Weight: 582.05
• Purity: ≥95%
• Synonyms: 2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid
• Target: Vitamin D Related/Nuclear Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 190/30 nM (hLXRα/β)
• InChI: InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
• InChIKey: NAXSRXHZFIBFMI-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4

GW3965(CAT: I003478) is a potent and selective agonist of liver X receptors (LXRs), including LXRα and LXRβ, nuclear receptors involved in cholesterol metabolism, lipid homeostasis, and inflammatory responses. By activating LXRs, GW3965 upregulates the expression of genes responsible for reverse cholesterol transport and decreases inflammation, making it a valuable tool for research in cardiovascular diseases, metabolic disorders, and atherosclerosis. Additionally, it supports studies on the role of LXRs in cancer and neurodegenerative diseases. With high specificity and reliability, GW3965 is suitable for in vitro and in vivo experiments, advancing understanding of LXR-mediated pathways and the development of therapeutic interventions.