For research use only. Not for therapeutic Use.
GW406381 (Cat.No:I007146) is a novel COX-2 inhibitor as a potential treatment for acute migraine. GW406381 is highly selective cyclooxygenase-2 (COX-2) inhibitor that is effective in animal models of central sensitization and of inflammatory pain. GW406381 attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. GW406381 is effective in animal models of neuropathic pain and central sensitization.
| Catalog Number | I007146 |
| CAS Number | 221148-46-5 |
| Synonyms | GW-406381; GW 406381; GW406381.;2-(4-ethoxyphenyl)-3-(4-(methylsulfonyl)phenyl)pyrazolo[1,5-b]pyridazine |
| Molecular Formula | C21H19N3O3S |
| Purity | ≥95% |
| Target | COX |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 2-(4-ethoxyphenyl)-3-(4-methylsulfonylphenyl)pyrazolo[1,5-b]pyridazine |
| InChI | InChI=1S/C21H19N3O3S/c1-3-27-17-10-6-16(7-11-17)21-20(19-5-4-14-22-24(19)23-21)15-8-12-18(13-9-15)28(2,25)26/h4-14H,3H2,1-2H3 |
| InChIKey | NXMZBNYLCVTRGB-UHFFFAOYSA-N |
| SMILES | CCOC1=CC=C(C=C1)C2=NN3C(=C2C4=CC=C(C=C4)S(=O)(=O)C)C=CC=N3 |
| Reference | </br>1:A randomized, controlled, dose-ranging study investigating single doses of GW406381, naproxen sodium, or placebo in patients with acute pain after third molar tooth extraction. Varner J, Lomax M, Blum D, Quessy S.Clin J Pain. 2009 Sep;25(7):577-83. doi: 10.1097/AJP.0b013e3181a085fa. PMID: 19692798 </br>2:A randomized, double-blind, placebo-controlled trial of a selective COX-2 inhibitor, GW406381, in patients with postherpetic neuralgia. Shackelford S, Rauck R, Quessy S, Blum D, Hodge R, Philipson R.J Pain. 2009 Jun;10(6):654-60. doi: 10.1016/j.jpain.2009.01.328. Epub 2009 May 5. PMID: 19409858 </br>3:Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies. Boswell DJ, Ostergaard K, Philipson RS, Hodge RA, Blum D, Brown JC, Quessy SN.Medscape J Med. 2008;10(11):259. Epub 2008 Nov 12. PMID: 19099009 Free PMC Article</br>4:A double-blind, randomized, placebo-controlled, single-dose study of the cyclooxygenase-2 inhibitor, GW406381, as a treatment for acute migraine. Wentz AL, Jimenez TB, Dixon RM, Aurora SK, Gold M; CXA20008 Study Investigators..Eur J Neurol. 2008 Apr;15(4):420-7. doi: 10.1111/j.1468-1331.2008.02093.x. Epub 2008 Feb 26. PMID: 18312401 </br>5:GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Zhao FY, Spanswick D, Martindale JC, Reeve AJ, Chessell IP.Pain. 2007 Mar;128(1-2):78-87. Epub 2006 Oct 19. PMID: 17055166 |
