For research use only. Not for therapeutic Use.
GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1].
GW438014A (10 mg/kg; i.p.; daily, for 7 d) inhibits spontaneous as well as overnight fasting-induced and NPY-induced feeding in rats and in food-deprived genetically obese ob/ob mice[1].
| Catalog Number | I011000 |
| CAS Number | 469861-49-2 |
| Synonyms | methanesulfonic acid;N-[1-(2-phenylethyl)benzimidazol-2-yl]benzamide |
| Molecular Formula | C23H23N3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H19N3O.CH4O3S/c26-21(18-11-5-2-6-12-18)24-22-23-19-13-7-8-14-20(19)25(22)16-15-17-9-3-1-4-10-17;1-5(2,3)4/h1-14H,15-16H2,(H,23,24,26);1H3,(H,2,3,4) |
| InChIKey | AVYFZOKRFCFQLP-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)O.C1=CC=C(C=C1)CCN2C3=CC=CC=C3N=C2NC(=O)C4=CC=CC=C4 |
| Reference | [1]. Daniels AJ, et, al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002 Jun 15;106(1-3):47-54. |
