For research use only. Not for therapeutic Use.
GW4869 is a noncompetitive inhibitor of neutral, magnesium-dependent sphingomyelinase (N-SMase) with an IC50 value of 1 μM. GW4869 did not inhibit acid SMase at up to at least 150 μM. *GW4869 is poorly soluble in DMSO and other common solvents. GW4869 is usually formulated as a suspension. GW4869 (TFA) has a better solubility and bioavailability than GW4869 (HCl).
KEYWORDS: GW4869 trifluoroacetate | supplier | N-SMase inhibitor | GW554869 TFA | GW 4869 | GW 554869 | GW-4869 | GW-554869 | CAS [475570-61-7] | Sphingolipid | PDE | Inhibitor | Enzymes | TNF
| Catalog Number | I047662 |
| CAS Number | 475570-61-7 |
| Molecular Formula | C30H28N6O2.2C2HF3O2 |
| Purity | ≥95% |
| Reference | C Luberto et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002;277(43):41128-41139. |
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