For research use only. Not for therapeutic Use.
GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].
| Catalog Number | R040345 |
| CAS Number | 660846-41-3 |
| Synonyms | tert-butyl 4-[(2-methoxyphenyl)carbamoyloxymethyl]piperidine-1-carboxylate |
| Molecular Formula | C19H28N2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H28N2O5/c1-19(2,3)26-18(23)21-11-9-14(10-12-21)13-25-17(22)20-15-7-5-6-8-16(15)24-4/h5-8,14H,9-13H2,1-4H3,(H,20,22) |
| InChIKey | SAXGSDIZIYFNKD-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCC(CC1)COC(=O)NC2=CC=CC=C2OC |
| Reference | [1]. Hougaard C, et, al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol. 2009 Sep;76(3):569-78. |
