GW806742X

For research use only. Not for therapeutic Use.

  • CAT Number: I019101
  • CAS Number: 579515-63-2
  • Molecular Formula: C₂₅H₂₂F₃N₇O₄S
  • Molecular Weight: 573.55
  • Purity: ≥95%
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GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2].<br>GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner[1].
GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM[2].


Catalog Number I019101
CAS Number 579515-63-2
Molecular Formula C₂₅H₂₂F₃N₇O₄S
Purity ≥95%
Reference

[1]. Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7.<br>[2]. Sammond DM, et al. Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase. Bioorg Med Chem Lett. 2005;15(15):3519-3523.

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