GW806742X

• CAT Number: I019101
• CAS Number: 579515-63-2
• Molecular Formula: C₂₅H₂₂F₃N₇O₄S
• Molecular Weight: 573.55
• Purity: ≥95%
• Target: Protein Tyrosine Kinase/RTK
• IUPAC Name: 1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
• InChI: InChI=1S/C25H22F3N7O4S/c1-35(22-13-14-30-23(34-22)31-18-3-2-4-21(15-18)40(29,37)38)19-9-5-16(6-10-19)32-24(36)33-17-7-11-20(12-8-17)39-25(26,27)28/h2-15H,1H3,(H2,29,37,38)(H,30,31,34)(H2,32,33,36)
• InChIKey: SNRUTMWCDZHKKM-UHFFFAOYSA-N
• SMILES: CN(C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)C3=NC(=NC=C3)NC4=CC(=CC=C4)S(=O)(=O)N

GW806742X(CAT: I019101) is a potent ATP-mimetic inhibitor of MLKL (Mixed Lineage Kinase Domain-Like protein) that binds the MLKL pseudokinase domain with a Kd of 9.3 μM. It effectively retards MLKL membrane translocation, thereby inhibiting necroptosis. Additionally, GW806742X demonstrates activity against VEGFR2, with an IC₅₀ of 2 nM, and inhibits VEGF-induced proliferation of HUVECs with an IC₅₀ of 5 nM. In mouse dermal fibroblasts, GW806742X blocks necroptotic cell death induced by TNF, Smac mimetic, and Q-VD-OPh in a dose-dependent manner. This compound is a valuable tool for studying necroptosis and VEGFR2-related pathways, with potential therapeutic implications for inflammatory and vascular diseases.