gyMneMic acid I

• CAT Number: M134532
• CAS Number: 122168-40-5
• Molecular Formula: C43H66O14
• Molecular Weight: 806.987
• Purity: ≥95%
• Synonyms: gyMneMic acid I
• Target: Autophagy
• Storage: -20°C
• IUPAC Name: (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8S,8aR,9R,10R,12aS,14aR,14bR)-8a-(acetyloxymethyl)-8,9-dihydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• InChI: InChI=1S/C43H66O14/c1-10-21(2)36(53)57-34-33(50)43(20-54-22(3)45)24(17-38(34,4)5)23-11-12-26-39(6)15-14-28(55-37-31(49)29(47)30(48)32(56-37)35(51)52)40(7,19-44)25(39)13-16-41(26,8)42(23,9)18-27(43)46/h10-11,24-34,37,44,46-50H,12-20H2,1-9H3,(H,51,52)/b21-10+/t24-,25+,26+,27-,28-,29-,30-,31+,32-,33-,34-,37+,39-,40-,41+,42+,43-/m0/s1
• InChIKey: VEFSVJGWJQPWFS-ZXKKMYOJSA-N
• SMILES: CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)O)O)O)C)COC(=O)C)O

Gymnemic acid I(CAT: M134532) is a triterpene glycoside found in Gymnema Sylvestre, a plant known for its antihyperglycemic properties. It has been shown to inhibit glucose-induced phosphorylation of certain proteins involved in cellular signaling, reduce caspase-3 activity, and induce autophagy in pancreatic β cells. At a concentration of 5 µg/ml, it has demonstrated these effects, making it a potential candidate for managing hyperglycemia and as a reference compound for studying sweet taste inhibitors derived from plants.