For research use only. Not for therapeutic Use.
H-0104 Dihydrochloride(CA: I012585) is a novel and potent Rho-associated coiled coil-formed protein kinase (ROCK) inhibitor with significant intraocular pressure (IOP)-lowering effects demonstrated in primate studies. By targeting the ROCK pathway, it promotes relaxation of trabecular meshwork cells, enhancing aqueous humor outflow and reducing IOP. This compound is a valuable tool in ophthalmology research, particularly for exploring therapeutic strategies for glaucoma and other ocular hypertension conditions. H-0104 Dihydrochloride represents a high-quality biochemical resource for advancing research in eye health and ROCK-mediated signaling pathways.
| Catalog Number | I012585 |
| CAS Number | 913636-88-1 |
| Synonyms | (2S)-1-[(4-Bromo-5-isoquinolinyl)sulfonyl]hexahydro-2-methyl-1H-1,4-diazepine dihydrochloride |
| Molecular Formula | C15H20BrCl2N3O2S |
| Purity | ≥95% |
| IUPAC Name | 4-bromo-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;dihydrochloride |
| InChI | InChI=1S/C15H18BrN3O2S.2ClH/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14;;/h2,4-5,9-11,17H,3,6-8H2,1H3;2*1H/t11-;;/m0../s1 |
| InChIKey | HVNZBMLWOCZURY-IDMXKUIJSA-N |
| SMILES | CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)Br.Cl.Cl |
