H-89 dihydrochloride

• CAT Number: I001184
• CAS Number: 130964-39-5
• Molecular Formula: C20H20BrN3O2S • 2HCl
• Molecular Weight: 519.30
• Purity: ≥95%
• Synonyms: (E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride
• Target: TGF-beta/Smad
• Solubility: DMSO: ≥ 50 mg/mL
• Storage: -20℃
• IC50: 48 nM
• IUPAC Name: N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide;dihydrochloride
• InChI: 1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+
• InChIKey: GELOGQJVGPIKAM-WTVBWJGASA-N
• SMILES: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl

H-89 Dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA), a key regulator of cellular processes like gene expression, metabolism, and cell growth. By blocking PKA activation, H-89 Dihydrochloride is used to study signaling pathways involving cyclic AMP (cAMP) and its role in various cellular functions. It is widely employed in cancer research, neurobiology, and studies related to inflammation, apoptosis, and cell proliferation. Its utility in elucidating PKA-dependent signaling makes it valuable for drug discovery and therapeutic development.