H-9 Dihydrochloride

• CAT Number: M020463
• CAS Number: 116700-36-8
• Molecular Formula: C11H15Cl2N3O2S
• Molecular Weight: 324.23
• Purity: ≥95%
• Synonyms: N-(2-aminoethyl)isoquinoline-5-sulfonamide;dihydrochloride
• InChI: InChI=1S/C11H13N3O2S.2ClH/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11;;/h1-4,6,8,14H,5,7,12H2;2*1H
• InChIKey: HBLCYSFLYMHCBM-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCN.Cl.Cl

H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3].
H-9 Dihydrochloride significantly inhibits A431 cells[1].
H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases[1].
H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration[2].

Reference

[1]. Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10(3):211-6.
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[2]. Vázquez-López A, et al. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005 May;30(5):613-8.
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[3]. Wollina U, et al. Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med. 2003 Oct;12(4):673-7.
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