For research use only. Not for therapeutic Use.
H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia[1][2].
H-Pro-Gly-Pro-OH (37.5 µg/kg; i.p.) activates the transcription of neurotrophins and their receptor genes after cerebral ischemia in rats[2].
| Catalog Number | I041618 |
| CAS Number | 7561-51-5 |
| Synonyms | (2S)-1-[2-[[(2S)-pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid |
| Molecular Formula | C12H19N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H19N3O4/c16-10(15-6-2-4-9(15)12(18)19)7-14-11(17)8-3-1-5-13-8/h8-9,13H,1-7H2,(H,14,17)(H,18,19)/t8-,9-/m0/s1 |
| InChIKey | BRPMXFSTKXXNHF-IUCAKERBSA-N |
| SMILES | C1CC(NC1)C(=O)NCC(=O)N2CCCC2C(=O)O |
| Reference | [1]. Patel DF, et al. The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017. [2]. Dmitrieva VG, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010 Jan;30(1):71-9. |
