For research use only. Not for therapeutic Use.
H2L5186303 (Cat.No:I007182) is a chemical compound with potential therapeutic applications. It has been studied for its activity as a selective antagonist of the H2 histamine receptor subtype. By blocking H2 receptor activation, H2L5186303 may have implications in the treatment of conditions associated with excessive gastric acid secretion, such as peptic ulcers and gastroesophageal reflux disease (GERD).
| Catalog Number | I007182 |
| CAS Number | 139262-76-3 |
| Synonyms | H2L5186303; H2L 5186303; H2L-5186303.;(Z)-4-oxo-N-[4-[3-[4-[[(Z)-4-oxobut-2-enoyl]amino]phenoxy]phenoxy]phenyl]but-2-enamide |
| Molecular Formula | C26H20N2O8 |
| Purity | ≥95% |
| Target | LPL Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at 4°C |
| IC50 | 8.9 nM |
| IUPAC Name | (Z)-4-[4-[3-[4-[[(Z)-3-carboxyprop-2-enoyl]amino]phenoxy]phenoxy]anilino]-4-oxobut-2-enoic acid |
| InChI | InChI=1S/C26H20N2O8/c29-23(12-14-25(31)32)27-17-4-8-19(9-5-17)35-21-2-1-3-22(16-21)36-20-10-6-18(7-11-20)28-24(30)13-15-26(33)34/h1-16H,(H,27,29)(H,28,30)(H,31,32)(H,33,34)/b14-12-,15-13- |
| InChIKey | HZFPOTBCYPWQSH-DZDAAMPGSA-N |
| SMILES | C1=CC(=CC(=C1)OC2=CC=C(C=C2)NC(=O)C=CC(=O)O)OC3=CC=C(C=C3)NC(=O)C=CC(=O)O |
| Reference | </br>1:Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. Structure-based drug design identifies novel LPA3 antagonists. Bioorg Med Chem. 2009 Nov 1;17(21):7457-64. doi: 10.1016/j.bmc.2009.09.022. PubMed PMID: 19800804; PubMed Central PMCID: PMC2771199. |
