H3B-6527

• CAT Number: I007183
• CAS Number: 1702259-66-2
• Molecular Formula: C29H34Cl2N8O4
• Molecular Weight: 629.54
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CCN1CCN(CC1)C2=CC(=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl)NC(=O)C=C

H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50 value of <1.2 nM and at least 250-fold selectivity over FGFR1-3 (IC50 values of 320, 1,290 and 1,060 nM respectively).

Reference

[1] Joshi JJ, et al. Cancer Res. 2017, 77(24):6999-7013.