For research use only. Not for therapeutic Use.
H3B-968(CAT: I040938) is a potent inhibitor of Werner syndrome protein (WRN), with an IC50 of approximately 10 nM. WRN is a critical enzyme with helicase, ATPase, and exonuclease activities, playing a vital role in DNA replication, repair, and maintenance of genomic stability. WRN is associated with aging disorders and exhibits synthetic lethal activity in cancer, where its inhibition can sensitize cancer cells to DNA damage. H3B-968 inhibits WRN helicase activity by competitively binding to ATP, disrupting DNA repair mechanisms. This compound is highly relevant for Cancer Disease Research, particularly in the development of targeted therapies for cancers with WRN dependency.
| CAS Number | 2912294-90-5 |
| Synonyms | N-(4-ethylphenyl)-2-[[4-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylamino]acetamide |
| Molecular Formula | C22H18F6N4O4S |
| Purity | ≥95% |
| IUPAC Name | N-(4-ethylphenyl)-2-[[4-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylamino]acetamide |
| InChI | InChI=1S/C22H18F6N4O4S/c1-2-13-3-7-15(8-4-13)30-19(33)12-29-37(34,35)20-31-17(11-18(32-20)21(23,24)25)14-5-9-16(10-6-14)36-22(26,27)28/h3-11,29H,2,12H2,1H3,(H,30,33) |
| InChIKey | ZLHLWRSVYPZIFD-UHFFFAOYSA-N |
| SMILES | CCC1=CC=C(C=C1)NC(=O)CNS(=O)(=O)C2=NC(=CC(=N2)C(F)(F)F)C3=CC=C(C=C3)OC(F)(F)F |
