For research use only. Not for therapeutic Use.
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP[1].
| Catalog Number | I040938 |
| CAS Number | 2912294-90-5 |
| Synonyms | N-(4-ethylphenyl)-2-[[4-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylamino]acetamide |
| Molecular Formula | C22H18F6N4O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H18F6N4O4S/c1-2-13-3-7-15(8-4-13)30-19(33)12-29-37(34,35)20-31-17(11-18(32-20)21(23,24)25)14-5-9-16(10-6-14)36-22(26,27)28/h3-11,29H,2,12H2,1H3,(H,30,33) |
| InChIKey | ZLHLWRSVYPZIFD-UHFFFAOYSA-N |
| SMILES | CCC1=CC=C(C=C1)NC(=O)CNS(=O)(=O)C2=NC(=CC(=N2)C(F)(F)F)C3=CC=C(C=C3)OC(F)(F)F |
| Reference | [1]. Parker MJ, et al. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Biochemistry. 2023 Jul 18;62(14):2147-2160. |
