HA-1077 (hydrochloride)

• CAT Number: R039760
• CAS Number: 203911-27-7
• Molecular Formula: C14H19Cl2N3O2S
• Molecular Weight: 364.29
• Purity: ≥95%
• Synonyms: Fasudil
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;dihydrochloride
• InChI: InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
• InChIKey: NOXXIYDYFSNHDF-UHFFFAOYSA-N
• SMILES: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl

HA-1077 (hydrochloride), also known as Fasudil, is a selective Rho-kinase inhibitor primarily used in research and clinical settings for its vasodilatory and neuroprotective properties. It works by inhibiting the Rho-kinase pathway, which plays a key role in regulating vascular smooth muscle contraction, cell migration, and inflammation. HA-1077 has been studied for its potential therapeutic applications in conditions like ischemic stroke, pulmonary hypertension, and cardiac remodeling. It is also being investigated for its potential benefits in neurodegenerative diseases.