For research use only. Not for therapeutic Use.
Antitumor agent-109 (compound 6) is an inhibitor of hyaluronic acid (HY-B0633A) targeting to CD44, as well as an anti-tumor agent. Hyaluronic acid interacts with differentiation cluster 44 (CD44) and is involved in tumor growth and invasion. Antitumor agent-109 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM[1].
| Catalog Number | I041003 |
| Synonyms | 5-bromo-2-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline |
| Molecular Formula | C19H22BrNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H22BrNO3/c1-22-17-9-13(10-18(23-2)19(17)24-3)11-21-8-7-15-14(12-21)5-4-6-16(15)20/h4-6,9-10H,7-8,11-12H2,1-3H3 |
| InChIKey | MGXKYGMIEHKJAA-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)CN2CCC3=C(C2)C=CC=C3Br |
| Reference | [1]. Espejo-Román JM, et al. N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect. Eur J Med Chem. 2023 Oct 5;258:115570. |
