HA15

• CAT Number: I002047
• CAS Number: 1609402-14-3
• Molecular Formula: C23H22N4O3S2
• Molecular Weight: 466.58
• Purity: ≥95%
• Target: target: BiP, GRP78, HSPA5 [1]
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-[4-[3-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]phenyl]-1,3-thiazol-2-yl]acetamide
• InChI: InChI=1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
• InChIKey: LBSMEKVVMYSTIH-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=NC(=CS1)C2=CC(=CC=C2)NS(=O)(=O)C3=CC=CC4=C3C=CC=C4N(C)C

HA15（Cat No.:I002047）is a small molecule inhibitor that targets the glucose-regulated protein 78 (GRP78), a key regulator of the unfolded protein response (UPR) in cells. By inhibiting GRP78, HA15 disrupts the protein-folding process within the endoplasmic reticulum, leading to cell stress, apoptosis, and autophagy, particularly in cancer cells. It has shown promise in treating various cancers, including melanoma and multiple myeloma, by inducing cell death in cancer cells while sparing normal cells. HA15 represents a novel therapeutic approach in targeting UPR and GRP78 in cancer research and treatment.

Reference

[1]. Cerezo M et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 Jun 13;29(6):805-19.