HA155

• CAT Number: M089801
• CAS Number: 1312201-00-5
• Molecular Formula: C24H19BFNO5S
• Molecular Weight: 463.29
• Purity: ≥95%

HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM[1][2][3].
HA-155 inhibits ATX by binding to the ATX active site[1].
HA155 completely attenuates the thrombin-mediated increase in platelet-derived LPA in a dose-dependent manner[3].

Reference

[1]. Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112(5):2593-603.
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[2]. Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54(13):4619-26.
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[3]. Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286(40):34654-63.
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