HAC-Y6

• CAT Number: I007186
• CAS Number: 1331959-78-4
• Molecular Formula: C23H22N2O4
• Molecular Weight: 390.43
• Purity: ≥95%
• Synonyms: HACY6; HAC-Y6; HAC Y6.;1-(9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indol-6-yl)ethanone
• Target: microtubule inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: 1-[9-[(3,4,5-trimethoxyphenyl)methyl]pyrido[2,3-b]indol-6-yl]ethanone
• InChI: InChI=1S/C23H22N2O4/c1-14(26)16-7-8-19-18(12-16)17-6-5-9-24-23(17)25(19)13-15-10-20(27-2)22(29-4)21(11-15)28-3/h5-12H,13H2,1-4H3
• InChIKey: NYMMDHGEECPYAW-UHFFFAOYSA-N
• SMILES: CC(=O)C1=CC2=C(C=C1)N(C3=C2C=CC=N3)CC4=CC(=C(C(=C4)OC)OC)OC

HAC-Y6(CAT: I007186) is a novel and potent microtubule inhibitor with demonstrated antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. By disrupting microtubule assembly, HAC-Y6 induces cell cycle arrest and apoptosis via both extrinsic and intrinsic pathways in Hep3B cells. Western blot and immunofluorescence studies reveal that HAC-Y6 depolymerizes microtubules in a manner similar to colchicine. Its mechanism makes it a valuable tool in cancer research, particularly for studying microtubule dynamics, cell cycle regulation, and apoptosis pathways. HAC-Y6 holds promise for advancing therapeutic strategies targeting HCC and other microtubule-dependent cancers.