For research use only. Not for therapeutic Use.
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity[1].
HAEGT (0-500 μM) is a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV)[1].
HAEGT can be catalyzed cleavage by DPP-IV with a km value of 38 μM, Kcat value of 3.1 S-1[1].
| Catalog Number | I020461 |
| CAS Number | 852155-81-8 |
| Synonyms | (4S)-4-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-5-[[2-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid |
| Molecular Formula | C20H31N7O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H31N7O9/c1-9(25-18(33)12(21)5-11-6-22-8-24-11)17(32)26-13(3-4-15(30)31)19(34)23-7-14(29)27-16(10(2)28)20(35)36/h6,8-10,12-13,16,28H,3-5,7,21H2,1-2H3,(H,22,24)(H,23,34)(H,25,33)(H,26,32)(H,27,29)(H,30,31)(H,35,36)/t9-,10+,12-,13-,16-/m0/s1 |
| InChIKey | LUWRDKLVTXFZFK-AWCHJOLGSA-N |
| SMILES | CC(C(C(=O)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC1=CN=CN1)N)O |
| Reference | [1]. Lisa M Kopcho, et al. Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach. Arch Biochem Biophys. 2005 Apr 15;436(2):367-76. |
