For research use only. Not for therapeutic Use.
Haemanthamine（Cat No.:I015559） is a snake venom-like alkaloid found in Amaryllidaceae plants, known for its potent anticancer activity. It exerts its effects by targeting the ribosome and inhibiting protein biosynthesis during the elongation phase of translation. Additionally, Haemanthamine demonstrates proapoptotic, antioxidant, antiviral, antimalarial, and anticonvulsant activities. These diverse properties make Haemanthamine an intriguing compound for further exploration and potential therapeutic applications in cancer treatment and various other conditions related to apoptosis, oxidative stress, viral infections, malaria, and seizures.
| Catalog Number | I015559 |
| CAS Number | 466-75-1 |
| Molecular Formula | C₁₇H₁₉NO₄ |
| Purity | ≥95% |
| Target | Anti-infection |
| Storage | Store at -20°C |
| IUPAC Name | (1S,13S,15S,18R)-15-methoxy-5,7-dioxa-12-azapentacyclo[10.5.2.01,13.02,10.04,8]nonadeca-2,4(8),9,16-tetraen-18-ol |
| InChI | InChI=1S/C17H19NO4/c1-20-11-2-3-17-12-6-14-13(21-9-22-14)4-10(12)7-18(8-16(17)19)15(17)5-11/h2-4,6,11,15-16,19H,5,7-9H2,1H3/t11-,15+,16+,17+/m1/s1 |
| InChIKey | YGPRSGKVLATIHT-HSHDSVGOSA-N |
| SMILES | COC1CC2C3(C=C1)C(CN2CC4=CC5=C(C=C34)OCO5)O |
| Reference | [1]. Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26(3):416-425.e4.<br>[2]. Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10. |
