Haloperidol

For research use only. Not for therapeutic Use.

  • CAT Number: A001033
  • CAS Number: 52-86-8
  • Molecular Formula: C21H23ClFNO2
  • Molecular Weight: 375.868
  • Purity: ≥95%
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Haloperidol, marketed under the trade name Haldol, is a typical antipsychotic medication. It is used in the treatment of schizophrenia, tics in Tourette syndrome, nausea and vomiting, delirium, agitation, acute psychosis, and hallucinations in alcohol withdrawal. It may be used by mouth, as an injection into a muscle, or intravenously. Haloperidol typically works within thirty to sixty minutes. A long-acting formulation may be used as an injection every four weeks in people with schizophrenia or related illnesses who either forget or refuse to take the medication by mouth.


Catalog Number A001033
CAS Number 52-86-8
Synonyms

52-86-8; Haldol; Aloperidin; Serenace; Aloperidol

Molecular Formula C21H23ClFNO2
Purity ≥95%
Target Dopamine Receptor
Solubility Soluble in DMSO > 10 mM
Storage -20°C
IUPAC Name 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
InChIKey LNEPOXFFQSENCJ-UHFFFAOYSA-N
SMILES C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
Reference

1: Slooff VD, van den Dungen DK, van Beusekom BS, Jessurun N, Ista E, Tibboel D,
de Wildt SN. Monitoring Haloperidol Plasma Concentration and Associated Adverse
Events in Critically Ill Children With Delirium: First Results of a Clinical
Protocol Aimed to Monitor Efficacy and Safety. Pediatr Crit Care Med. 2017 Dec
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29239979.
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2: Lei K, He GF, Zhang CL, Liu YN, Li J, He GZ, Li XP, Ren XH, Liu D.
Investigation of the synergistic effects of haloperidol combined with Calculus
Bovis Sativus in treating MK-801-induced schizophrenia in rats. Exp Anim. 2017
Dec 8. doi: 10.1538/expanim.17-0091. [Epub ahead of print] PubMed PMID: 29225304.
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3: Fahmy AM, El-Setouhy DA, Ibrahim AB, Habib BA, Tayel SA, Bayoumi NA.
Penetration enhancer-containing spanlastics (PECSs) for transdermal delivery of
haloperidol: in vitro characterization, ex vivo permeation and in vivo
biodistribution studies. Drug Deliv. 2018 Nov;25(1):12-22. doi:
10.1080/10717544.2017.1410262. PubMed PMID: 29219628.
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4: van Keulen K, Knol W, Schrijver EJM, van Marum RJ, van Strien AM, Nanayakkara
PWB. Prophylactic Use of Haloperidol and Changes in Glucose Levels in
Hospitalized Older Patients. J Clin Psychopharmacol. 2018 Feb;38(1):51-54. doi:
10.1097/JCP.0000000000000812. PubMed PMID: 29210808.
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5: Benvegnú DM, Roversi K, Barcelos RCS, Trevizol F, Pase CS, Segat HJ, Dias VT,
Savian AL, Piccoli BL, Piccolo J, Dutra-Filho CS, Emanuelli T, de Bona da Silva
C, Beck RCR, Burger ME. Effects of Fish and Grape Seed Oils as Core of
Haloperidol-Loaded Nanocapsules on Oral Dyskinesia in Rats. Neurochem Res. 2017
Dec 5. doi: 10.1007/s11064-017-2444-0. [Epub ahead of print] PubMed PMID:
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6: Lum JS, Pan B, Deng C, Huang XF, Ooi L, Newell KA. Effects of short- and
long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens:
Comparison with haloperidol. Psychiatry Res. 2017 Nov 21;260:152-157. doi:
10.1016/j.psychres.2017.11.048. [Epub ahead of print] PubMed PMID: 29195167.
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7: Teale EA. Haloperidol for delirium prevention: uncertainty remains. Age
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8: Lencesova L, Szadvari I, Babula P, Kubickova J, Chovancova B, Lopusna K,
Rezuchova I, Novakova Z, Krizanova O, Novakova M. Disruption of dopamine D1/D2
receptor complex is involved in the function of haloperidol in cardiac H9c2
cells. Life Sci. 2017 Dec 15;191:186-194. doi: 10.1016/j.lfs.2017.10.026. Epub
2017 Oct 18. PubMed PMID: 29054453.
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9: Nikoli&#263; T, Petronijevi&#263; M, Sopta J, Velimirovi&#263; M, Stojkovi&#263; T, Jevti&#263; Do&#382;udi&#263;
G, Aksi&#263; M, Radonji&#263; NV, Petronijevi&#263; N. Haloperidol affects bones while
clozapine alters metabolic parameters – sex specific effects in rats perinatally
treated with phencyclidine. BMC Pharmacol Toxicol. 2017 Oct 11;18(1):65. doi:
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PMC5637335.
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10: Schrijver EJM, de Vries OJ, van de Ven PM, Bet PM, Kamper AM, Diepeveen SHA,
van Marum RJ, van Strien AM, Anten S, Lagaay AM, Boelaarts L, Bloemers FW, Kramer
MHH, Nanayakkara PWB. Haloperidol versus placebo for delirium prevention in
acutely hospitalised older at risk patients: a multi-centre double-blind
randomised controlled clinical trial. Age Ageing. 2018 Jan 1;47(1):48-55. doi:
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