Haloperidol D4

• CAT Number: I000685
• CAS Number: 1189986-59-1
• Molecular Formula: C21H19D4ClFNO2
• Molecular Weight: 379.89
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 4-[4-(4-chloro-2,3,5,6-tetradeuteriophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
• InChI: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2/i5D,6D,7D,8D
• InChIKey: LNEPOXFFQSENCJ-KDWZCNHSSA-N
• SMILES: [2H]C1=C(C(=C(C(=C1C2(CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F)O)[2H])[2H])Cl)[2H]

Haloperidol-d4 is a deuterated form of the antipsychotic drug haloperidol, where four hydrogen atoms are replaced with deuterium. This isotopically labeled compound is used in pharmaceutical research to study the drug’s pharmacokinetics, metabolism, and mechanism of action. The deuterium atoms allow for precise tracking in mass spectrometry, making it easier to differentiate the labeled compound from its non-labeled counterpart. Haloperidol-d4 is particularly valuable for exploring the metabolic pathways and interactions of haloperidol in the treatment of psychiatric disorders such as schizophrenia. This compound aids researchers in optimizing dosing strategies and minimizing side effects, contributing to the development of more effective antipsychotic therapies.