For research use only. Not for therapeutic Use.
Hamamelitannin（Cat No.:469-32-9）is a natural polyphenolic compound found in the bark and leaves of witch hazel (Hamamelis virginiana), known for its potent antioxidant, anti-inflammatory, and antimicrobial properties. It functions by neutralizing free radicals and reducing oxidative stress, making it beneficial in skincare products for soothing and protecting the skin. In addition, Hamamelitannin has been studied for its ability to disrupt bacterial biofilm formation, particularly in Staphylococcus aureus, enhancing its potential as a natural antimicrobial agent. Its diverse bioactivity makes it valuable in dermatology, cosmetics, and infection control research.
| Catalog Number | I017294 |
| CAS Number | 469-32-9 |
| Molecular Formula | C₂₀H₂₀O₁₄ |
| Purity | ≥95% |
| Target | Bacterial |
| IUPAC Name | [(2S,3S,4S)-3,4,5-trihydroxy-4-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxolan-2-yl]methyl 3,4,5-trihydroxybenzoate |
| InChI | InChI=1S/C20H20O14/c21-9-1-7(2-10(22)14(9)25)17(28)32-5-13-16(27)20(31,19(30)34-13)6-33-18(29)8-3-11(23)15(26)12(24)4-8/h1-4,13,16,19,21-27,30-31H,5-6H2/t13-,16-,19?,20-/m0/s1 |
| InChIKey | FEPAFOYQTIEEIS-WZKFEGCESA-N |
| SMILES | C1=C(C=C(C(=C1O)O)O)C(=O)OC[C@H]2[C@@H]([C@](C(O2)O)(COC(=O)C3=CC(=C(C(=C3)O)O)O)O)O |
| Reference | [1]. Kiran MD, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol. 2008 May;73(5):1578-86.<br>[2]. Cobrado L, et al. In vivo antibiofilm effect of cerium, chitosan and hamamelitannin against usual agents of catheter-related bloodstream infections. J Antimicrob Chemother. 2013 Jan;68(1):126-30.<br>[3]. Sánchez-Tena S, et al. Hamamelitannin displays specific cytotoxic activity against colon cancer cells. J Nat Prod. 2012 Jan 27;75(1):26-33. |
