Harmine

• CAT Number: I003564
• CAS Number: 442-51-3
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.25
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC

Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.

Reference

[1] Waki H, et al. Cell Metab. 2007, 5(5):357-70.
[2] Xi-Ling Jiang, et al. Drug Metab Dispos. 2013, 41(5): 975-986.