Harringtonine

• CAT Number: I002921
• CAS Number: 26833-85-2
• Molecular Formula: C28H37NO9
• Molecular Weight: 531.60
• Purity: ≥95%
• Synonyms: 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine
• Target: Influenza Virus
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate
• InChI: InChI=1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1
• InChIKey: HAVJATCHLFRDHY-KSZYUSJVSA-N
• SMILES: CC(C)(CC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O

Harringtonine（Cat No.:I002921）is a potent alkaloid derived from the plant Cephalotaxus harringtonia, known for its significant role in cancer research. It functions as an inhibitor of protein synthesis by targeting the elongation factor eEF2, thereby halting translation in cells. This mechanism makes it valuable in the study of cellular processes and as a potential chemotherapeutic agent. Harringtonine has shown activity against various cancers, including leukemia and solid tumors, and is of interest in drug development for its ability to selectively inhibit cancer cell growth while sparing normal cells.

Reference

[1]. Fresno M, et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977 Jan;72(2):323-30.

[2]. Kaur P, et al. Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. Antimicrob Agents Chemother. 2013 Jan;57(1):155-67.

[3]. Yunmbam MK, et al. Combinatorial treatment of ovarian cancer cells with harringtonine and cisplatin results in increased cisplatin-DNA adducts. Oncol Rep. 2004 Apr;11(4):833-8.