Hawkinsin

• CAT Number: I028617
• CAS Number: 63224-90-8
• Molecular Formula: C11H17NO6S
• Molecular Weight: 291.32
• Purity: 98%
• Synonyms: Hawkinsin
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-Cyclohexene-1-acetic acid, 6-((2-amino-2-carboxyethyl)thio)-1,4-dihydroxy-
• InChI: InChI=1S/C11H17NO6S/c12-7(10(16)17)5-19-8-3-6(13)1-2-11(8,18)4-9(14)15/h1-2,6-8,13,18H,3-5,12H2,(H,14,15)(H,16,17)
• InChIKey: SPXVLTDISXZSFM-UHFFFAOYSA-N
• SMILES: NC(CSC1CC(O)C=CC1(O)CC(=O)O)C(=O)O

Hawkinsin (Cat No.: I028617) is a rare cyclic amino acid derivative associated with the metabolic disorder hawkinsinuria. It is an intermediate in the tyrosine degradation pathway, accumulating due to a deficiency in 4-hydroxyphenylpyruvate dioxygenase (HPD) enzyme activity. Hawkinsinuria is characterized by transient metabolic acidosis, growth retardation, and specific urinary metabolites. Treatment typically involves dietary modifications, including tyrosine and phenylalanine restriction. Hawkinsin’s biochemical properties and role in amino acid metabolism provide insights into metabolic disorders and potential therapeutic interventions for affected individuals.