For research use only. Not for therapeutic Use.
HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling[1][2].
HaXS8 promotes intracellular dimerization of Halo-GFP and SNAP-GFP fusion proteins reached >65%, and displays significant intracellular dimerization as low as 50 nM in HeLa cells[1].
HaXS8 (0.5 μM; 40 min) induces a rapid and efficient cross-linking of the membrane anchor and the iSH2 construct, and triggers the activation of the downstream targets PKB/Akt and mTOR in HEK293 cells[1].
HaXS8 (0.5 μM; 40 min) does not upregulate MAPK phosphorylation in HEK293 cells[1].
HaXS8 (0.5 μM; 1 h) does not interfere with PI3K/mTOR signaling in HEK293 cells[1].
| Catalog Number | I045473 |
| CAS Number | 2080306-25-6 |
| Synonyms | N-[[4-[(2-amino-7H-purin-6-yl)oxymethyl]phenyl]methyl]-2-[4-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethoxy]-2,3,5,6-tetrafluorophenoxy]acetamide |
| Molecular Formula | C35H43ClF4N6O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C35H43ClF4N6O8/c36-9-3-1-2-4-10-48-11-12-49-13-14-50-15-16-51-17-18-52-31-26(37)28(39)32(29(40)27(31)38)53-21-25(47)42-19-23-5-7-24(8-6-23)20-54-34-30-33(44-22-43-30)45-35(41)46-34/h5-8,22H,1-4,9-21H2,(H,42,47)(H3,41,43,44,45,46) |
| InChIKey | OHHUCZCSUXJJFO-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CNC(=O)COC2=C(C(=C(C(=C2F)F)OCCOCCOCCOCCOCCCCCCCl)F)F)COC3=NC(=NC4=C3NC=N4)N |
| Reference | [1]. Erhart D, et, al. Chemical development of intracellular protein heterodimerizers. Chem Biol. 2013 Apr 18; 20(4): 549-57. [2]. Saha I, et, al. Dynamics of the HIV Gag Lattice Detected by Localization Correlation Analysis and Time-Lapse iPALM. Biophys J. 2020 Aug 4; 119(3): 581-592. |
