For research use only. Not for therapeutic Use.
HBC525 is a HBC-like fluorophore and a fluorogenic RNA aptamer (Kd=3.8 nM). HBC525 can be directly used as fusion tags for the imaging and tracking of cellular RNAs of interest. Fluorogenic RNA aptamers have also been used to construct various interesting dynamic RNA nanodevices for cellular target detection and imaging[1][2].
荧光RNA适体
| Catalog Number | I045311 |
| CAS Number | 2174014-64-1 |
| Synonyms | (E)-2-(1,3-benzoxazol-2-yl)-3-[4-[2-hydroxyethyl(methyl)amino]phenyl]prop-2-enenitrile |
| Molecular Formula | C19H17N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H17N3O2/c1-22(10-11-23)16-8-6-14(7-9-16)12-15(13-20)19-21-17-4-2-3-5-18(17)24-19/h2-9,12,23H,10-11H2,1H3/b15-12+ |
| InChIKey | PARAUTMXYRINAC-NTCAYCPXSA-N |
| SMILES | CN(CCO)C1=CC=C(C=C1)C=C(C#N)C2=NC3=CC=CC=C3O2 |
| Reference | [1]. Chen X, et al. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol. 2019;37(11):1287-1293. [2]. Yu Q, et al. Genetically encoded RNA nanodevices for cellular imaging and regulation. Nanoscale. 2021;13(17):7988-8003. |
