For research use only. Not for therapeutic Use.
HBT1 is an AMPA receptor potentiator with lower agonistic effect, avoiding bell-shaped response in vitro BDNF production.
| Catalog Number | I028622 |
| CAS Number | 489408-02-8 |
| Synonyms | HBT1; HBT-1; HBT 1 |
| Molecular Formula | C16H17F3N4O2S |
| Purity | 98% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-(((5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
| InChI | InChI=1S/C16H17F3N4O2S/c1-8-6-11(16(17,18)19)22-23(8)7-12(24)21-15-13(14(20)25)9-4-2-3-5-10(9)26-15/h6H,2-5,7H2,1H3,(H2,20,25)(H,21,24) |
| InChIKey | PHLXSNIEQIKENK-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(NC(CN2N=C(C(F)(F)F)C=C2C)=O)SC3=C1CCCC3)N |
| Reference | 1: Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820. |
