For research use only. Not for therapeutic Use.
HC-030031 (Cat.No:I003279) is a selective inhibitor of the Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel. TRPV1 is involved in pain transmission and inflammation. HC-030031 has been studied for its potential in pain management and as an anti-inflammatory agent. It blocks TRPV1 activation, offering a potential therapeutic approach for pain-related conditions.
| Catalog Number | I003279 |
| CAS Number | 349085-38-7 |
| Synonyms | 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide |
| Molecular Formula | C18H21N5O3 |
| Purity | ≥95% |
| Target | TRP Channel |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20℃ powder |
| IC50 | 6.2 uM |
| IUPAC Name | 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide |
| InChI | InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24) |
| InChIKey | HEQDZPHDVAOBLN-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C |
| Reference | </br>1:Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences. Gupta R, Saito S, Mori Y, Itoh SG, Okumura H, Tominaga M.Sci Rep. 2016 Nov 22;6:37460. doi: 10.1038/srep37460. PMID: 27874100 Free PMC Article</br>2:Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system. Pereira LM, Lima-Júnior RC, Bem AX, Teixeira CG, Grassi LS, Medeiros RP, Marques-Neto RD, Callado RB, Aragão KS, Wong DV, Vale ML, Brito GA, Ribeiro RA.Eur J Pain. 2013 Feb;17(2):223-33. doi: 10.1002/j.1532-2149.2012.00177.x. Epub 2012 Jun 11. PMID: 22689151 </br>3:HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, Henze DA, Kane SA, Urban MO.Mol Pain. 2008 Oct 27;4:48. doi: 10.1186/1744-8069-4-48. PMID: 18954467 Free PMC Article |
