HC-5404

• CAT Number: I040164
• CAS Number: 2247396-91-2
• Molecular Formula: C24H24F2N4O3
• Molecular Weight: 454.47
• Purity: ≥95%
• Synonyms: 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-methylphenyl]-N-propan-2-ylpyridine-3-carboxamide
• InChI: InChI=1S/C24H24F2N4O3/c1-12(2)29-23(32)20-9-15(11-28-22(20)27)19-5-4-18(6-13(19)3)30-24(33)21(31)14-7-16(25)10-17(26)8-14/h4-12,21,31H,1-3H3,(H2,27,28)(H,29,32)(H,30,33)/t21-/m1/s1
• InChIKey: BRIWRAFDHZTJPE-OAQYLSRUSA-N
• SMILES: CC1=C(C=CC(=C1)NC(=O)C(C2=CC(=CC(=C2)F)F)O)C3=CC(=C(N=C3)N)C(=O)NC(C)C

HC-5404 (Cat No.:I040164) is a small-molecule compound that acts as a selective inhibitor of specific protein kinases involved in cell signaling pathways, particularly those regulating cell growth and survival. It has shown promise in preclinical studies as a potential therapeutic agent for various cancers, by interfering with key oncogenic signaling networks. HC-5404’s ability to modulate cellular processes such as apoptosis, cell proliferation, and metastasis positions it as a candidate for further development in oncology, with a focus on improving tumor control and overcoming resistance mechanisms.

Reference

[1]. Michael E Stokes, et al. PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors. Clin Cancer Res. 2023, 29, 3.
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[2]. Veronica Calvo, et al. A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells. Clin Cancer Res. 2023.
[Content Brief]