HC Toxin

• CAT Number: R047492
• CAS Number: 83209-65-8
• Molecular Formula: C₂₁H₃₂N₄O₆
• Molecular Weight: 436.51
• Purity: ≥95%
• Synonyms: Toxin I (Helminthosporium carbonum)
• Storage: -20°C
• IUPAC Name: (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
• InChI: InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17-/m0/s1
• InChIKey: GNYCTMYOHGBSBI-SVZOTFJBSA-N
• SMILES: C[C@@H]1C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C)CCCCCC(=O)[C@@H]3CO3

HC toxin（Cat No.:R047492）is a mycotoxin produced by the fungus Helminthosporium carbonum, primarily affecting corn and other cereals. It is known for its phytotoxic properties, leading to necrosis and stunting in plants, which can significantly impact agricultural yields. HC toxin acts by inhibiting protein synthesis, disrupting cellular processes in susceptible plants. Research into its mechanisms has also revealed potential implications in understanding plant-pathogen interactions and developing resistant crop varieties. Additionally, its effects on animal and human health are of interest, particularly regarding exposure and toxicity studies related to contaminated food sources.

Reference

1.Brosch, G.,Ransom, R.,Lechner, T., et al. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. Plant Cell 7, 1941-1950 (1995).