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6205-14-7-HCA HCA

HCA

For research use only. Not for therapeutic Use.

  • CAT Number: I028639
  • CAS Number: 6205-14-7
  • Molecular Formula: C6H8O8
  • Molecular Weight: 208.12
  • Purity: 60%
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Related Small Molecules: 1,3-Dimethylpyrazole     Blinin     ganosporeric acid A    

HCA (Cat.No:I028639) refers to Hydroxycitric acid, a natural compound derived from the fruit of Garcinia cambogia. It is commonly used as a weight loss supplement due to its potential to inhibit an enzyme called citrate lyase, which is involved in fatty acid synthesis. HCA has also been studied for its effects on appetite suppression and improving exercise performance.


Catalog Number I028639
CAS Number 6205-14-7
Synonyms

HCA; (±)-Hydroxycitric Acid; (±) Hydroxycitric Acid;

Molecular Formula C6H8O8
Purity 60%
Target Plants
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 1,2-dihydroxypropane-1,2,3-tricarboxylic acid
InChI InChI=1S/C6H8O8/c7-2(8)1-6(14,5(12)13)3(9)4(10)11/h3,9,14H,1H2,(H,7,8)(H,10,11)(H,12,13)
InChIKey ZMJBYMUCKBYSCP-UHFFFAOYSA-N
SMILES O=C(O)CC(C(O)C(O)=O)(O)C(O)=O
Reference

1: John OD, Mouatt P, Panchal SK, Brown L. Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats. Nutrients. 2021 Jan 22;13(2):319. doi: 10.3390/nu13020319. PMID: 33499382.
2: Bibyk MJ, Campbell MJ, Hummon AB. Mass-spectrometric investigations of caloric restriction mimetics. Proteomics. 2021 Jan 18:e2000121. doi: 10.1002/pmic.202000121. Epub ahead of print. PMID: 33460282.
3: Abdelhameed RM, Rocha J, Silva AMS. Selective separation of hibiscus acid from Roselle extracts by an amino-functionalized Metal Organic Framework. J Chromatogr A. 2021 Jan 11;1636:461789. doi: 10.1016/j.chroma.2020.461789. Epub 2020 Dec 8. PMID: 33326926.
4: Cruz AC, Pinto AHS, Costa CDD, Oliveira LP, Oliveira-Neto JR, Cunha LC. Food- Effect on (-) – Hydroxycitric Acid Absorption After Oral Administration of Garcinia cambogia Extract Formulation: a Phase I, Randomized, Cross-Over Study. J Pharm Sci. 2021 Feb;110(2):693-697. doi: 10.1016/j.xphs.2020.10.035. Epub 2020 Oct 24. PMID: 33164784.
5: Li L, Chu X, Yao Y, Cao J, Li Q, Ma H. (-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels. J Agric Food Chem. 2020 Oct 7;68(40):11229-11241. doi: 10.1021/acs.jafc.0c04648. Epub 2020 Sep 25. PMID: 32940033.
6: Ferreira V, Mathieu A, Soucy G, Giard JM, Erard-Poinsot D. Acute Severe Liver Injury Related to Long-Term Garcinia cambogia Intake. ACG Case Rep J. 2020 Aug 11;7(8):e00429. doi: 10.14309/crj.0000000000000429. PMID: 32821764; PMCID: PMC7423904.
7: Li M, Li X, Yang L. Cardioprotective effects of garcinol following myocardial infarction in rats with isoproterenol-induced heart failure. AMB Express. 2020 Aug 4;10(1):137. doi: 10.1186/s13568-020-01065-9. PMID: 32749545; PMCID: PMC7403263.
8: Baroni MD, Colombo S, Libens O, Pallavi R, Giorgio M, Martegani E. In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. Apoptosis. 2020 Oct;25(9-10):686-696. doi: 10.1007/s10495-020-01625-1. PMID: 32666259; PMCID: PMC7527365.
9: Fan QX, Gong SQ, Hong XZ, Feng XM, Zhang FJ. Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models. Eur Rev Med Pharmacol Sci. 2020 Jun;24(11):6434-6445. doi: 10.26355/eurrev_202006_21542. PMID: 32572941.
10: de Carvalho Cruz A, Suenaga EM, Prova SS, de Oliveira Neto JR, Ifa DR, da Cunha LC. New bioanalytical method for the quantification of (-) – hydroxycitric acid in human plasma using UPLC-MS/MS and its application in a Garcinia cambogia pharmacokinetic study. J Pharm Biomed Anal. 2020 Sep 5;188:113385. doi: 10.1016/j.jpba.2020.113385. Epub 2020 May 23. PMID: 32505893.
11: Ismail A, Doghish AS, E M Elsadek B, Salama SA, Mariee AD. Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase. Steroids. 2020 Aug;160:108656. doi: 10.1016/j.steroids.2020.108656. Epub 2020 May 18. PMID: 32439410.
12: Bhutani P, U R, H N S, Ranjanna PK, Paul AT. Rapid and cost-effective LC- MS/MS method for determination of hydroxycitric acid in plasma: Application in the determination of pharmacokinetics in commercial Garcinia preparations. Biomed Chromatogr. 2020 Oct;34(10):e4902. doi: 10.1002/bmc.4902. Epub 2020 Jun 11. PMID: 32428251.
13: Li L, Jiang Z, Yao Y, Yang Z, Ma H. (-)-Hydroxycitric acid regulates energy metabolism by activation of AMPK – PGC1α – NRF1 signal pathway in primary chicken hepatocytes. Life Sci. 2020 Aug 1;254:117785. doi: 10.1016/j.lfs.2020.117785. Epub 2020 May 13. PMID: 32416167.
14: Liu X, Yuan P, Sun X, Chen Z. Hydroxycitric Acid Inhibits Renal Calcium Oxalate Deposition by Reducing Oxidative Stress and Inflammation. Curr Mol Med. 2020;20(7):527-535. doi: 10.2174/1566524020666200103141116. PMID: 31902360.
15: Ibuki M, Shoda C, Miwa Y, Ishida A, Tsubota K, Kurihara T. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20):5049. doi: 10.3390/ijms20205049. PMID: 31614647; PMCID: PMC6834364.
16: Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: Case report. Eur J Ophthalmol. 2020 Nov;30(6):NP21-NP26. doi: 10.1177/1120672119872364. Epub 2019 Oct 3. PMID: 31578090.
17: Patel D, Buch A. Improvisation of a spectrophotometric method to quantify hydroxycitric acid. Anal Biochem. 2019 Dec 1;586:113412. doi: 10.1016/j.ab.2019.113412. Epub 2019 Aug 29. PMID: 31473244.

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