HDAC-IN-40

• CAT Number: I043566
• CAS Number: 2463198-51-6
• Molecular Formula: C15H22N2O6
• Molecular Weight: 326.34
• Purity: ≥95%
• Synonyms: N-[6-(hydroxyamino)-6-oxohexoxy]-3,5-dimethoxybenzamide
• InChI: InChI=1S/C15H22N2O6/c1-21-12-8-11(9-13(10-12)22-2)15(19)17-23-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19)
• InChIKey: WARMWIVORGODLX-UHFFFAOYSA-N
• SMILES: COC1=CC(=CC(=C1)C(=O)NOCCCCCC(=O)NO)OC

HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects[1].
HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively[1].
HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR[1].
HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1].

Reference

[1]. Yodita Asfaha, et al. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem. 2020 Jan 1;28(1):115108.
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