HDAC10-IN-2 hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I041233
  • Molecular Formula: C19H23ClN2O2
  • Molecular Weight: 346.85
  • Purity: ≥95%
Inquiry Now

HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 hydrochloride modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells[1].


Catalog Number I041233
Synonyms

(E)-N-hydroxy-3-[1-(naphthalen-1-ylmethyl)piperidin-4-yl]prop-2-enamide;hydrochloride

Molecular Formula C19H23ClN2O2
Purity ≥95%
InChI InChI=1S/C19H22N2O2.ClH/c22-19(20-23)9-8-15-10-12-21(13-11-15)14-17-6-3-5-16-4-1-2-7-18(16)17;/h1-9,15,23H,10-14H2,(H,20,22);1H/b9-8+;
InChIKey DZIBQQUCYKFHSE-HRNDJLQDSA-N
SMILES C1CN(CCC1C=CC(=O)NO)CC2=CC=CC3=CC=CC=C32.Cl
Reference

[1]. Zeyen P, et al. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 2022 Apr 15;234:114272.
 [Content Brief]

Request a Quote