For research use only. Not for therapeutic Use.
HDAC6 Degrader-3（Cat No.:I042283）is a selective small molecule compound designed to target and degrade HDAC6 (histone deacetylase 6), an enzyme involved in regulating various cellular processes such as protein degradation, cell motility, and stress response. HDAC6 plays a role in cancer, neurodegenerative diseases, and inflammatory conditions. By utilizing a targeted protein degradation approach, HDAC6 Degrader-3 selectively induces the degradation of HDAC6, potentially inhibiting its pathological effects. This strategy holds promise in treating diseases where HDAC6 contributes to tumor growth, inflammation, or cellular dysfunction, offering a novel approach to therapeutic intervention.
| Catalog Number | I042283 |
| CAS Number | 2785404-83-1 |
| Synonyms | 4-[[5-[8-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]octanoylamino]-2-methylbenzimidazol-1-yl]methyl]-3-fluoro-N-hydroxybenzamide;2,2,2-trifluoroacetic acid |
| Molecular Formula | C41H41F4N7O11 |
| Purity | ≥95% |
| IUPAC Name | 4-[[5-[8-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]octanoylamino]-2-methylbenzimidazol-1-yl]methyl]-3-fluoro-N-hydroxybenzamide;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C39H40FN7O9.C2HF3O2/c1-22-42-28-19-25(13-14-29(28)46(22)20-24-12-11-23(18-27(24)40)36(51)45-55)43-32(48)10-5-3-2-4-6-17-41-34(50)21-56-31-9-7-8-26-35(31)39(54)47(38(26)53)30-15-16-33(49)44-37(30)52;3-2(4,5)1(6)7/h7-9,11-14,18-19,30,55H,2-6,10,15-17,20-21H2,1H3,(H,41,50)(H,43,48)(H,45,51)(H,44,49,52);(H,6,7) |
| InChIKey | YHRIRNOBNMKZIJ-UHFFFAOYSA-N |
| SMILES | CC1=NC2=C(N1CC3=C(C=C(C=C3)C(=O)NO)F)C=CC(=C2)NC(=O)CCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O.C(=O)(C(F)(F)F)O |
