hDHODH-IN-1

• CAT Number: I016863
• CAS Number: 1173715-42-8
• Molecular Formula: C17H14N2O2
• Molecular Weight: 278.31
• Purity: ≥95%
• Synonyms: (Z)-2-cyano-3-hydroxy-N-(4-phenylphenyl)but-2-enamide
• InChI: InChI=1S/C17H14N2O2/c1-12(20)16(11-18)17(21)19-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,20H,1H3,(H,19,21)/b16-12-
• InChIKey: MUVPBAIVOHJDOC-VBKFSLOCSA-N
• SMILES: CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C2=CC=CC=C2)O

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory effect[1].
Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. Because DHODH is required to ensure proliferating-cell viability, inhibitors have been developed to eliminate human DHODH (hDHODH) activity, which is associated with cancers, multiple sclerosis, and autoimmune and inflammatory diseases[1].

Reference

[1]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.
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